Wenyi Wei Selected Research

Proteolysis Targeting Chimera

3/2024	Structurally Specific Z-DNA Proteolysis Targeting Chimera Enables Targeted Degradation of Adenosine Deaminase Acting on RNA 1.
11/2022	Targeting micro-environmental pathways by PROTACs as a therapeutic strategy.
1/2022	PROTACs technology for treatment of Alzheimer's disease: Advances and perspectives.
1/2022	Cell cycle on the crossroad of tumorigenesis and cancer therapy.
1/2021	Folate-Guided Protein Degradation by Immunomodulatory Imide Drug-Based Molecular Glues and Proteolysis Targeting Chimeras.
1/2021	Cancer Selective Target Degradation by Folate-Caged PROTACs.
12/2020	PROTACs: A novel strategy for cancer therapy.

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Wenyi Wei Research Topics

Disease

122	Neoplasms (Cancer) 04/2024 - 05/2002
50	Carcinogenesis 01/2024 - 04/2003
13	Prostatic Neoplasms (Prostate Cancer) 01/2023 - 01/2012
11	Neoplasm Metastasis (Metastasis) 11/2022 - 12/2013
9	Melanoma (Melanoma, Malignant) 01/2022 - 08/2013
9	Breast Neoplasms (Breast Cancer) 01/2021 - 03/2011
3	Chronic Obstructive Pulmonary Disease (COPD) 04/2024 - 11/2021
3	Insulin Resistance 12/2023 - 12/2017
3	Pathologic Processes 09/2023 - 01/2018
3	Inflammation (Inflammations) 07/2023 - 12/2017
3	Hypoxia (Hypoxemia) 07/2023 - 01/2016
3	Neurodegenerative Diseases (Neurodegenerative Disease) 01/2022 - 10/2018
3	Leukemia 01/2022 - 09/2017
3	Lung Neoplasms (Lung Cancer) 10/2021 - 02/2017
3	Genomic Instability 01/2018 - 01/2015
3	Precursor T-Cell Lymphoblastic Leukemia-Lymphoma (T-ALL) 11/2014 - 03/2011
2	Hepatocellular Carcinoma (Hepatoma) 05/2024 - 01/2017
2	Triple Negative Breast Neoplasms 04/2024 - 01/2018
2	COVID-19 12/2023 - 01/2021
2	Infections 12/2023 - 12/2020
2	Bites and Stings (Sting) 10/2023 - 01/2023
2	Obesity 01/2023 - 03/2020
2	Alzheimer Disease (Alzheimer's Disease) 01/2022 - 10/2018
2	Kidney Neoplasms (Kidney Cancer) 01/2020 - 12/2016
2	Pancreatic Neoplasms (Pancreatic Cancer) 01/2020 - 01/2015
2	Stomach Neoplasms (Stomach Cancer) 01/2019 - 01/2018
2	Starvation 01/2018 - 01/2018
2	Colonic Neoplasms (Colon Cancer) 03/2011 - 05/2002
1	Liver Neoplasms (Liver Cancer) 01/2024
1	Brain Ischemia (Cerebral Ischemia) 12/2023

Drug/Important Bio-Agent (IBA)

47	Proteins (Proteins, Gene)FDA Link 05/2024 - 03/2011
30	Ubiquitin-Protein Ligases (Ubiquitin-Protein Ligase)IBA 04/2024 - 09/2010
24	Phosphotransferases (Kinase)IBA 01/2024 - 11/2004
19	Ligases (Synthetase)IBA 05/2024 - 01/2012
19	Oncogene Proteins (Oncogene Protein)IBA 04/2024 - 03/2011
17	UbiquitinIBA 05/2024 - 01/2012
9	F-Box ProteinsIBA 01/2023 - 03/2011
8	DNA (Deoxyribonucleic Acid)IBA 10/2023 - 01/2015
8	Mechanistic Target of Rapamycin Complex 2IBA 01/2022 - 11/2013
7	Proteolysis Targeting ChimeraIBA 03/2024 - 12/2020
7	snake venom protein C activatorIBA 03/2024 - 01/2019
6	Mechanistic Target of Rapamycin Complex 1IBA 12/2023 - 12/2014
6	Proteasome Endopeptidase Complex (Proteasome)IBA 10/2023 - 05/2013
6	Glucose (Dextrose)FDA LinkGeneric 01/2023 - 05/2012
6	Phosphoric Monoester Hydrolases (Phosphatases)IBA 12/2021 - 04/2014
5	Protein Kinases (Protein Kinase)IBA 05/2024 - 01/2014
5	EnzymesIBA 01/2023 - 01/2012
5	Deubiquitinating EnzymesIBA 01/2023 - 01/2017
5	Immune Checkpoint InhibitorsIBA 10/2022 - 01/2018
5	B7-H1 AntigenIBA 10/2022 - 01/2018
5	Transcription Factors (Transcription Factor)IBA 01/2022 - 01/2016
5	Cullin Proteins (Cullins)IBA 01/2019 - 12/2016
4	S-Phase Kinase-Associated Proteins (Skp1 Protein)IBA 05/2024 - 01/2012
4	CyclinsIBA 01/2023 - 01/2017
4	LigandsIBA 10/2022 - 01/2018
3	Peptidylprolyl Isomerase (Prolyl Isomerase)IBA 04/2024 - 06/2012
3	MethyltransferasesIBA 09/2023 - 12/2015
3	Programmed Cell Death 1 ReceptorIBA 01/2023 - 01/2018
3	Biomarkers (Surrogate Marker)IBA 01/2022 - 02/2016
3	Amyloid (Amyloid Fibrils)IBA 01/2022 - 12/2017
3	TensinsIBA 12/2021 - 01/2020
3	Androgen Receptors (Androgen Receptor)IBA 01/2020 - 01/2012
3	Tumor Suppressor Proteins (Proteins, Tumor Suppressor)IBA 01/2015 - 12/2013
3	Cyclin EIBA 04/2014 - 03/2011
2	Cyclin-Dependent Kinases (cdk Proteins)IBA 04/2024 - 01/2017
2	ChromatinIBA 02/2024 - 01/2023
2	N-methyladenosineIBA 09/2023 - 01/2020
2	CytokinesIBA 09/2023 - 01/2023
2	6-methyladenineIBA 01/2023 - 01/2020
2	Arginine (L-Arginine)FDA Link 01/2023 - 01/2018
2	AntibodiesIBA 11/2022 - 10/2022
2	Histones (Histone)IBA 10/2022 - 01/2019
2	A-Form DNA (A-DNA)IBA 01/2022 - 01/2019
2	Folic Acid (Vitamin M)FDA LinkGeneric 01/2021 - 01/2021
2	Mitogen-Activated Protein Kinase Kinases (MEKs)IBA 01/2021 - 01/2017
2	Phosphatidylinositols (Phosphatidylinositol)IBA 01/2021 - 11/2014
2	Cadherins (E-Cadherin)IBA 01/2018 - 11/2012
2	Ribosomal Protein S6 Kinases (S6 Kinase)IBA 01/2018 - 01/2018
2	Estrogen ReceptorsIBA 01/2017 - 01/2012
2	Anaphase-Promoting Complex-CyclosomeIBA 01/2016 - 04/2014
2	PTEN Phosphohydrolase (PTEN Phosphatase)IBA 09/2015 - 04/2014
2	Trastuzumab (Herceptin)FDA Link 11/2012 - 05/2012
2	ABT-737IBA 03/2011 - 03/2011
2	Sorafenib (BAY 43-9006)FDA Link 03/2011 - 03/2011
2	Cullin 1IBA 03/2011 - 09/2010
1	Heat-Shock Proteins (Heat-Shock Protein)IBA 05/2024
1	bafilomycin A1IBA 05/2024
1	Chloroquine (Aralen)FDA LinkGeneric 05/2024
1	Z-Form DNA (Z-DNA)IBA 03/2024
1	Carrier Proteins (Binding Protein)IBA 03/2024
1	Intergenic DNA (Junk DNA)IBA 02/2024
1	Anti-Obesity Agents (Antiobesity Drugs)IBA 01/2024
1	Peptides (Polypeptides)IBA 01/2024
1	Orlistat (Xenical)FDA Link 01/2024
1	Angiotensin-Converting Enzyme 2IBA 12/2023
1	Methionine (L-Methionine)FDA Link 12/2023
1	lobetyolinIBA 12/2023
1	OligodeoxyribonucleotidesIBA 10/2023

Therapy/Procedure

37	Therapeutics 10/2023 - 02/2012
11	Immunotherapy 10/2023 - 12/2018